The accumulation of mercaptopurine metabolites in age fractionated red blood cells.
نویسندگان
چکیده
منابع مشابه
An improved HPLC method for the quantitation of 6-mercaptopurine and its metabolites in red blood cells.
A procedure is described for the rapid determination of the intra-erythrocyte concentration of 6-mercaptopurine (6-MP) and its metabolites, 6-thioguanine nucleotides (6-TGN) and 6-methylmercaptopurine (6-MMP). Erythrocytes (8 x 10(8) cells) in 350 microl Hanks solution containing 7.5 mg dithiothreitol were treated with 50 microl 70% perchloric acid. The precipitate was removed by centrifugation...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1995
ISSN: 0306-5251,1365-2125
DOI: 10.1111/j.1365-2125.1995.tb05776.x